Area of Interest
My lab investigates the molecular and cellular mechanisms underlying tissue morphogenesis. The formation of three-dimensional tubular structures from flat epithelial sheets is a key process of organ formation in all animals, including mammalian lungs, kidney and digestive organs. Yet, we do not fully understand how such dramatic changes in tissue structures occur on a cellular level, and what molecular components regulate this fundamental process. My approach takes advantage of powerful Drosophila genetics, live imaging and computational analysis. Specifically, using Drosophila embryonic tubular epithelia as models, I seek to understand how the forces driving spatiotemporal changes in cell shape, arrangement and position are generated and transmitted during epithelial tube formation. These studies provide a basis for understanding general processes of organogenesis.
Positions Available- We are recruiting 1-2 PhD students (to begin Fall 2018; application deadline Jan 10) and a postdoctoral fellow (position immediately available). If interested, please email Dr. SeYeon Chung (email@example.com).
SeYeon Chung, Sangjoon Kim and Deborah J. Andrew (2017). Uncoupling apical constriction from tissue invagination. eLife 6:e22235. https://www.ncbi.nlm.nih.gov/pubmed/28263180
SeYeon Chung and Deborah J. Andrew (2014). Cadherin 99C regulates apical expansion and cell rearrangement during epithelial tube elongation. Development 141:1950-1960. https://www.ncbi.nlm.nih.gov/pubmed/24718992
SeYeon Chung, Cy Chavez and Deborah J. Andrew (2011). Trachealess (Trh) regulates all tracheal genes during Drosophila embryogenesis. Dev Biol 360: 160-172. https://www.ncbi.nlm.nih.gov/pubmed/21963537
SeYeon Chung, Melissa S. Vining, Pamela L. Bradley, Chih-Chiang Chan, Keith A. Wharton, Jr. and Deborah J. Andrew. (2009). Serrano (Sano) functions with the planar cell polarity genes to control tracheal tube length. PLoS Genet 5: e1000746. https://www.ncbi.nlm.nih.gov/pubmed/19956736
SeYeon Chung, Sangjoon Kim, Jeongsook Yoon, Paul N. Adler and Jeongbin Yim. (2007). The balance between the novel protein target of wingless and the Drosophila Rho-associated kinase pathway regulates planar cell polarity in the Drosophila wing. Genetics 176:891-903. https://www.ncbi.nlm.nih.gov/pubmed/17409077
SeYeon Chung, Caitlin D. Hanlon and Deborah J. Andrew (2014). Building and Specializing epithelial tubular organs: the Drosophila salivary gland as a model system for revealing how epithelial organs are specified, form and specialize. Wiley Interdiscip Rev Dev Biol 3: 281-300. https://www.ncbi.nlm.nih.gov/pubmed/25208491
SeYeon Chung and Deborah J. Andrew. (2008). The formation of epithelial tubes. J Cell Sci 121: 350-3504. https://www.ncbi.nlm.nih.gov/pubmed/18946020