Tammy Dugas

Professor, Department of Comparative Biomedical Sciences, LSU School of Veterinary Medicine

LSU Superfund Research Program Oxidative Stress Core leader.  

 Tammy Dugas


Phone: (225) 578-7581

Fax: (225) 578-9895

Email: tammydugas@lsu.edu

Website: http://www.lsu.edu/vetmed/cbs/people/faculty/dugas.php


Research interests, expertise:

  • Mechanisms of cardiovascular injury induced by environmental toxicants and by pharmaceuticals
  • Mechanisms for cardioprotection by red wine polyphenols


Recent publications:



Jaligama, S., Chen, Z., Saravia, J., Yadev, N., Lomnicki, S., Dugas, T., Cormier, S.A. 2015. Exposure to Deepwater Horizon Crude Oil Burnoff Particulate Matter induces Pulmonary Inflammation and Alters Adaptive Immune Response. Environ. Sci. Technol. 49 (14):8769-8776. DOI: 10.1021/acs.est.5b01439. Publication Date (Web)L June 26, 2015. 



Lee, G., Saravia, J., You, D., Shrestha, B., Jaligama, S., Hebert, V., Dugas. T., Cormier, S. 2014. Exposure to Combustion Generated Environmentally Persistent Free Radicals Enhances Severity of Influenza virus Infection. Part Fibre Toxicol. 11(1):57. Doi:10.1186/s12989-014-0057-1. [Epub ahead of print]


Lomnicki, S., Gullett, B, Stöger,T., Kennedy, I., Diaz, J., Dugas, T.R., Varner, K., Carlin, D., Dellinger, B., and Cormier, S.A. 2013. Combustion By-Products and their Health Effects - Combustion Engineering and Global Health in the 21st Century: Issues and Challenges. International Journal of Toxicology. 33(1):3-13. Doi: 10.1177/1091581813519686. PMCID: PMC3944372 



Kelley, M.A., Hebert, V.Y., Thibeaux, T.M., Orchard, M.A., Hasan, F., Cormier, S.A., Thevenot, P.T., Lomnicki, S.M., Varner,K.J., Dellinger, B, Latimer, B.M., Dugas, T.R. 2013. Model Combustion-Generated Particulate Matter Containing Persistent Free Radicals Redox Cycle to Produce Reactive Oxygen Species. Chem. Res. Toxicol. 26(12):1862-71. Doi: 10.1021/tx400227s.


Thevenot, P., Saravia, J., Giammo, J., Happel, K.I., Dugas, T.R. and Cormier, S.A. 2013. Chronic Alcohol Induces M2 Polarization Enhancing Pulmonary Disease Caused by Exposure to Particulate Air Pollution. Alcoholism: Clinical and Experimental Research. 37(11): 1910-1919.Doi: 10.1111/acer.12184. PMCID: PMC3775861


Thevenot P.T., Saravia J., Jin N, Giaimo J.D., Chustz R.E., Mahne S., Kelley M.A., Hebert V.Y., Dellinger B., Dugas T.R., Demayo F.J., Cormier S.A. 2013. Radical-containing ultrafine particulate matter initiates epithelial-to-mesenchymal transitions in airway epithelial cells. American Journal of Respiratory Cell and Molecular Biology. 48:188-197. Doi: 10.1165/rcmb.2012-0052OC. PMCID: PMC3604062


Xue, S.Y., Hebert, V.Y., Hayes, D.M., Robinson, C.N., Glover, M., and Dugas, T.R. 2013. Nucleoside reverse transcriptase inhibitors induce a mitophagy-associated endothelial cytotoxicity that is reversed by coenzyme Q10 cotreatment. Toxicol Sci. 134(2):323-34.



Khandelwal, A.R., Hebert, V.Y., Kleinedler, J.J., Rogers, L.K., Ullevig, S.L., Asmis, R., Shi, R., Dugas, T.R. 2012. Resveratrol and quercetin interact to inhibit neointimal hyperplasia in mice with a carotid injury. J Nutr. 142(2):1487-94.


Kleinedler, J.J., Pjescic, I., Bullock, K.K., Khaliq, A., Foley, J.D., Dugas, T.R. 2012. Arterial pharmacokinectics of red wine polyphenols: implications for novel endovascular therapies targeting restenosis. J Pharm Sci. 101(5):1917-31.


Kleinedler, J.J., Foley, J.D., Orchard, E.A., Dugas, T.R. 2012. Novel nanocomposite stent coating releasing resveratrol and quercetin reduces neointimal hyperplasia and promotes re-endothelialization. J Control Release. 159(1):27-33.



Kelley, M.A., Thibeaux, T., Hebert, V., Cormier, S.A., Lomnicki, S., Dillinger, B., Dugas, T. 2011. Model Particulate Matter Containing Persistent Free Radicals Exhibit Reactive Oxygen Species Production. Free Radical Biology and Medicine. 51(1):S134. 


Lord, K., Moll, D., Lindsey, J.K., Mahne, S., Raman, G., Dugas, T., Cormier, S., Troxlair, D., Lomnicki, S., Dellinger, B., & Varner, K. 2011. Environmentally persistent free radicals decrease cardiac function before and after ischemia/reperfusion injury in vivo. J Recept Signal Transduct Res. 31(2):157-67. Doi: 10.3109/10799893.2011.555767. PMCID:PMC3152960



Khandelwal, A.R., Hebert,V.Y., Kleiner, H.E., and Dugas, T.R. 2010. Essential role of an ER-α dependent production of nitric oxide in modulating the anti-restenotic effects of resveratrol. Am. J. Physiol. Heart & Circ. Physiol. 299:H1451-1458.


Jiang, B., Khandelwal, A.R., Rogers, L.K., Zavecz, J.H., Shi, W., Orr, A.W., and Dugas, T.R. 2010. Antiretrovirals induce endothelial dysfunction via an oxidant-dependent pathway and promote neointimal hyperplasia in C57BL/6 mice. Toxicol. Sci. 117:524-36.